Laboratory Websiterlerner@@scripps.edu
(858) 784-8265
 Laboratory: Lab of Antibody Design
Research Interest: Technological innovation and application of combinatorial antibody libraries.
 Scripps Research Joint AppointmentsDepartment of Chemistry
The Skaggs Institute for Chemical Biology
 EducationM.D., Medicine, Stanford University, 1964
B.S., Stanford University, 1959
 Awards & Professional Activities1970 - NIH AID Career Development Award
1978 - Parke Davis Award
1985 - Elected Foreign Member, The Royal Swedish Academy of Sciences
1986 - Recipient of Lita Annenberg Hazen Professor of Immunochemistry
1986 - Decorated as oficial de La Orden de San Carlos by the President of Colombia
1989 - Cecil H. and Ida M. Green Chair in Chemistry
1990 - Honorary Doctorate of Medicine, Karolinska Institute
1990 - John A. Muntz Memorial Prize, Albany Medical College, New York
1990 - San Marino Prize, Republic of San Marino
1990 - The Burroughs Wellcome Fund and the FASEB Wellcome Visiting Professor Award in Basic Medical Science
1991 - The College De France Lectureship, College De France, Paris
1991 - Arthur C. Cope Scholar Award in Chemistry, Washington, D.C.
1992 - CIBA-Geigy Drew Prize in Chemical Science, Drew University, Madison, New Jersey
1993 - Hyp J. Dauben Award in Chemistry, University of Washington, Seattle, Washington
1994 - Humboldt Research Award, Bonn Germany
1994/95 - The Wolf Prize in Chemistry
1996 - California Scientist of the Year Award
1999 - William B Coley Award for Distinguished Research in Basic and Tumor Immunology, Cancer Research Institute, New York, NY
1999 - Windaus-Medal/Award, Georg-August-Universit t G ttingen, G ttingen Germany
2001 - Honorary Doctorate of Science Award Doctor Scientiarum Honoris Causa, Technion-Israel Institute of Technology, Technion City, Haifa, Israel 2002 - Doctor of Science, Northwestern University, Evanston, IL
2002 - Scientist of the Year Award, ARCS Foundation, Inc., San Diego, CA
2002 - President's Medal, University of California
2003 - Paul Ehrlich-and Ludwig Darmstaedter Prize, Frankfurt, Germany
2003 - Honorary Doctorate Degree, Ben-Gurion University of the Negev, Beer-Sheva, Israel
2004 - Honorary Doctorate in Humane Letters from Florida Atlantic University, Boca Raton, Florida
2005 - AAAS Fellow
2005 - DART/NYU Biotechnology Achievement Award in Basic Biotechnology, New York, NY
2006 - Distinguished Visiting Scientist at IBM T.J. Watson Research Center, New York
2007 - Honorary Degree of Doctor of Science, honoris causa, Oxford University, Oxford, United Kingdom Editorial Boards: Journal of Virology, Molecular Biology and Medicine, Vaccine, Bioorganic and Medicinal Chemistry Letters, Drug Targeting and Delivery, Bioorganic and Medicinal Chemistry, Molecular Medicine, Catalysis Technology, Angewandte Chemie
2012 - Prince of Asturis award
 Selected publications1.“A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union.” Grover RK, Zhu X, Nieusma T, Jones T, Boero I, MacLeod AS, Mark A, Niessen S, Kim HJ, Kong L, Assad-Garcia N, Kwon K, Chesi M, Smider VV, Salomon DR, Jelinek DF, Kyle RA, Pyles RB, Glass JI, Ward AB, Wilson IA, Lerner RA. Science. 2014 Feb 7;343(6171):656-61
2.“Prevention of cell death by antibodies selected from intracellular combinatorial libraries.” Xie J, Yea K, Zhang H, Moldt B, He L, Zhu J, Lerner RA. Chem Biol. 2014 Feb 0;21(2):274-83.
3.“Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections.” Yea K, Zhang H, Xie J, Jones TM, Yang G, Song BD, Lerner RA. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37)
4.“Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells.” Xie J, Zhang H, Yea K, Lerner RA. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8099-104.
5.“A proximity based general method for identification of ligand and receptor interactions in living cells. Zhang H, Xie J, Lerner RA. Biochem Biophys Res Commun.” 2014 Oct 24;454(1):251-255.
6.“Selecting agonists from single cells infected with combinatorial antibody libraries.” Zhang H, Yea K, Xie J, Ruiz D, Wilson IA, Lerner RA. Chem Biol. 2013 May 23;20(5):734-41.
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