Co-PI, Research Associate Professor, Lab of ADC ChemistryShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech UniversityEmail: chenhl@@shanghaitech.edu.cn
Address: Room A403
Education
2009 Ph.D., Medicinal Chemistry, Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
2004 B.S., Chemistry, Lanzhou University, Gansu, China.
Publications1. Huang, R.; Zhu W.; Wu Y.; Chen, J. K.; Yu, J. H.; Jiang B.*; Chen, H. L.*; Chen, W. Z.*, A novel mass spectrometry-cleavable, phosphate-based enrichable and multi-targeting protein cross-linker, Chem. Sci., 2019, 10, 6443-6447. (co-corresponding)
2. Huang, R.; Li, Z. H.; Yu, J. H.; Chen, H. L.*; Jiang B.*, H2O Regulated Chemoselectivity in Oxa- Versus Aza-Michael Reactions, Org. Lett., 2019, 21, 4159-4162. (co-corresponding)
3. Huang, R.; Li, Z. H.; Sheng, Y.; Yu, J. H.; Wu, Y.; Zhan, Y. X.; Chen, H. L.*; Jiang B.*, N-Methyl- N-phenylvinylsulfonamides for Cysteine-Selective Conjugation, Org. Lett., 2018, 20, 6526-6529. (co-corresponding)
4. Huang, R.; Li, Z. H.; Ren, P. L.; Chen, W. Z.; Kuang, Y. Y.; Chen, J. K.; Zhan, Y. X.; Chen, H. L.*; Jiang B.*, N‐Phenyl‐N‐aceto‐vinylsulfonamides as Efficient and Chemoselective Handles for N‐Terminal Modification of Peptides and Proteins, Eur. J. Org. Chem., 2018, 829-836. (co-corresponding)
5. Li, Z. H.; Huang, R.; Xu, H. T.; Chen, J. K.; Zhan, Y. X.; Zhou, X. H.; Chen, H. L.*; Jiang B.*, Divinylsulfonamides as Specific Linkers for Stapling Disulfide Bonds in Peptides, Org. Lett., 2017, 19, 4972–4975 (co-corresponding)
6. Chen, H. L.*; Huang, R.; Li, Z. H.; Zhu, W.; Chen, J. K.; Zhan, Y. X.; Jiang B.*, Selective lysine modification of native peptides via aza-Michael addition, Org. Biomol. Chem., 2017, 15, 7339 – 7345 (co-corresponding)
7. Liu, X. Y.; Xu, H. T.; Zhan, Y. X.; Ma, P. X.*; Chen, H. L.*; Jiang B.*, Tris(2-carboxyethyl)phosphine promotes hydrolysis of imonoboronates, Tetrahedron Lett., 2017 58, 3101-3106 (co-corresponding)
8. Wang, H.; Zhou, F.; Ren, G.R.; Zheng, Q. H.; Chen, H. L.; Gao, B.; Klivansky, L.; Liu, Y.; Wu, B.; Xiu, Q. F.; Lu, J. M.; Sharpless, K. B.; Wu, P., SuFEx-Based Polysulfonate Formation from Ethenesulfonyl Fluoride-Amine Adducts, Angew Chem Int Ed Engl;, 2017, 56, 11203 – 11208.
9. Chen, H. L.*; Han, C. J.; Wu, J.; Liu, X. Y.; Zhan, Y. X.; Chen, J. K.; Chen, Y. K.; Gu, R. N.; Zhang, L.; Chen, S. S.; Jia, J.; Zhen, X. C.; Zheng, L. T.*; Jiang B.*, Accessible Method for the Development of Novel Sterol Analogues with Dipeptide-like Side Chains That Act as Neuroinflammation Inhibitors, ACS Chem. Neurosci., 2016, 7, 305-315. (co-corresponding)
